منابع مشابه
Global alignment of protein-protein interaction networks.
Sequence-based comparisons have been the workhorse of bioinformatics for the past four decades, furthering our understanding of gene function and evolution. Over the last decade, a plethora of technologies have matured for measuring Protein-protein interactions (PPIs) at large scale, yielding comprehensive PPI networks for over ten species. In this chapter, we review methods for harnessing PPI ...
متن کاملGlobal Alignment of Multiple Protein Interaction Networks
UNLABELLED We describe an algorithm for global alignment of multiple protein-protein interaction (PPI) networks, the goal being to maximize the overall match across the input networks. The intuition behind our algorithm is that a protein in one PPI network is a good match for a protein in another network if the former's neighbors are good matches for the latter's neighbors. We encode this intui...
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Global health networks, webs of individuals and organizations with a shared concern for a particular condition, have proliferated over the past quarter century. They differ in their effectiveness, a factor that may help explain why resource allocations vary across health conditions and do not correspond closely with disease burden. Drawing on findings from recently concluded studies of eight gl...
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Global health networks—webs of individuals and organizations linked by a shared concern for a particular condition—have proliferated over the past quarter century. In a recent editorial in this journal, I presented evidence that their effectiveness in addressing four challenges—problem definition, positioning, coalitionbuilding and governance—shapes their ability to influence policy. The editor...
متن کاملLocality of Global Stochastic Interaction in Directed Acyclic Networks
The hypothesis of invariant maximization of interaction (IMI) is formulated within the setting of random fields. According to this hypothesis, learning processes maximize the stochastic interaction of the neurons subject to constraints. We consider the extrinsic constraint in terms of a fixed input distribution on the periphery of the network. Our main intrinsic constraint is given by a directe...
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ژورنال
عنوان ژورنال: Cambridge Review of International Affairs
سال: 2003
ISSN: 0955-7571,1474-449X
DOI: 10.1080/09557570302054